Disrupting bacterial communication to counteract virulence and biofilm formation


Many plant pathogens rely on bacterial communication to enter in a pathogenic cycle and induce disease on host plants. Limiting bacterial communication can be a strategy to protect plants from certain pathogens such as Erwinia amylovora that induces fireblight on apple and pear trees and Erwinia sp., Pectobacterium sp. or Pseudomonas sp. responsible for soft rot disease on tubers, corn and bulbs.




Bacterial infections represent a major constraint for the development of aquaculture across the world. The use of disinfectants or antibiotics has only limited success and is prone to develop resistance phenomenon that can potentially threaten human health. VesuBACT offers an alternative to decrease pathogenicity of bacteria (e.g. Aeromonas sp. and Vibrio sp.) in fish farms with less selection pressure on microorganisms limiting the risks of occurrence of resistance.  


Medical devices

Bacterial infections are problematic in health facilities and often found with catheter associated urinary tract infections or wound complications. VesuBACT can be immobilized on medical devices (catheter, dressings...) to limit biofilm formation and prevent virulence.


Biofouling is an important issue in industrial processes involving filtration and for surfaces in contact with seawater such as boats, nets or pipelines. Incorporation of VesuBACT in paints or coatings to protect surfaces is a solution to decrease biofilm formation and limit fouling issues.