History


Issued from the French academic research, Gene&GreenTK was founded in 2013 on the basis of the work of Prof. Eric Chabrière and Dr. Mikael Elias in close collaboration with the French Defense Procurement Agency (DGA).  

The phosphotriesterase from Sulfolobus solfataricus (SsoPox) was first investigated for bioedecontamination purposes. This enzyme is able to degrade organophosphorus compounds and shows a tremendous robustness paving the way for biotechnological applications.

Surprisingly, this enzyme was also shown to have a lactonase activity for the hydrolysis of acyl-homoserines lactones involved in the communication of Gram negative bacteria (e.g. Pseudomonas aeruginosa, Acinetobacter baumannii ...)

From these earliest works many other extremophile enzymes have been isolated and engineered with two main objectives :

 


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